SPRINT-MIND is a randomized controlled trial of intensive systolic blood pressure control to a target of under 120 mmHg and is the first major trial to demonstrate that an intervention reduces the incidence of....

Network analysis reveals interesting relationships between GDS items, functional disability and dementia risk. We discuss...

Depressive symptoms account for a significant portion of the variance in disability...

(T)here is increasing evidence suggesting that depression is a risk factor for AD. Studies in mice subject to chronic stress showed impaired glymphatic circulation and alteration in AQP4 expression leading to increased cerebral Aβ accumulation. Interestingly, treatment with fluoxetine was...